Endocrine Abstracts

Objective: The NHS long term plan aims to identify 25% of the Familial Hypercholesterolaemia (FH) patients in England by 2025. This study aimed to identify patients with FH, assess their classification according to the Dutch Lipid Clinic Network (DLCN) criteria, and evaluate treatment outcomes.Methods: We conducted a retrospective analysis of patients referred for assessment of possible FH who went on to have genetic tes...

Case report: A 40-year-old lady was diagnosed with acromegaly in 1993 after presentation with clinical symptoms. Imaging showed a 1 cm pituitary lesion and she underwent transphenoidal hypophysectomy in 1993. Post-operatively she was rendered hypopituitary, but still had biochemical evidence of active acromegaly. She proceeded to external beam radiotherapy and was started on bromocriptine medical therapy.On routine review in 2006, her acromegaly was bioc...

A 25-year-old pregnant lady presented to the accident and emergency department at 16 weeks gestation with intractable vomiting, weight loss and lethargy. She reported a 2 months history of hyperemesis gravidarum managed in the community prior to admission.She had no past medical history and her only medication was of a Polish antenatal vitamin containing 400 IU of Vitamin D (D2). Her blood biochemistry revealed a markedly raised corrected calcium at 3.57...

The amelioration of type 2 diabetes and sustained weight loss after bariatric surgery are thought to be due to elevated circulating levels of the gut hormones peptide YY3–36 (PYY3–36) and glucagon-like peptide-1 (GLP-1). GLP-1 augments the insulin response to an oral glucose load. PYY3–36 has appetite-inhibitory effects and contributes to longer-term weight loss. Rodent studies provide conflicting data regarding the effects of PY...